Hulk (2003)

Hulk is the 2003 film directed by Ang Lee, based on the Marvel Comics character. Bruce Banner experiments with gamma radiation for the purposes of healing wounds and regenerating tissue. An accident exposes him to a seemingly lethal dose of radiation; he survives, but when angered he transforms into the green-skinned behemoth of the title.

F-22 Raptor
An F-22 is sent to bring down the Hulk when he returns to San Francisco & seeks refuge on the Golden Gate Bridge. When the plane is about to crash into the bridge, the Hulk leaps upon it to prevent a collision. The pilot responds by flying to an extreme altitude to shake the Hulk off, which succeeds, however, the pilot flies too high & floats into space while the Hulk plummets into San Francisco Bay.